Esther Castellano leads the Tumor:Stroma signalling group at Centro de Investigación del Cáncer in Salamanca.
She completed her PhD in Eugenio’s Santos Lab at Centro de Investigación del Cáncer in Salamanca, where she uncovered that HRAS and NRAS oncogenes have specific functions.
After finishing her PhD Esther moved to Julian Downward’s Lab at London Research Institute, now part of the Francis Crick Institute, in London where she continued working on RAS oncogenes, but this time on the role of RAS activation of PI3K in lung cancer.
After her postdoctoral training she moved to Barts Cancer Institute as an Early Career PI and in 2018 she moved to Centro de Investigación del Cancer in Salamanca as an independent researcher. Her lab focuses on understanding how oncogenic RAS proteins drive lung cancer development by regulating the interplay between tumour cells and its microenvironment.